Pharmacokinetics of 0.75% ropivacaine and 0.5% bupivacaine after ilioinguinal–iliohypogastric nerve block in children

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Pharmacokinetics of 0.75% ropivacaine and 0.5% bupivacaine after ilioinguinal-iliohypogastric nerve block in children.

BACKGROUND Blockade of the ilioinguinal and iliohypogastric nerves is a useful procedure in paediatric patients undergoing inguinal surgery. Bupivacaine 2 mg kg-1 has been recommended for this block. We compared the plasma concentrations of ropivacaine and bupivacaine following an ilioinguinal-iliohypogastric block. METHODS Forty children scheduled for elective inguinal surgery were randomize...

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ROPIVACAINE is an amide local anesthetic with a long duration of action that was developed because of the high risk of cardiac complications induced by bupivacaine. Preclinical studies have confirmed its reduced systemic and cardiac toxicity as compared with bupivacaine, and clinical studies have also been very reassuring regarding the risk of ropivacaine-induced systemic toxicity. There have, ...

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Ropivacaine versus levobupivacaine in peripheral nerve block

BACKGROUND To determine which is more potent in peripheral nerve block between ropivacaine and levobupivacaine. METHODS A literature search was performed in the EMBASE, Medline, the Cochrane Library, and the Web of Science. The trials that were found were then evaluated for eligibility. The Cochrane Collaboration's Review Manager software was used to perform the meta-analyses. RESULTS Twelv...

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Arterial and venous pharmacokinetics of ropivacaine with and without epinephrine after thoracic paravertebral block.

BACKGROUND Animal and volunteer studies indicate that ropivacaine is associated with less neurologic and cardiac toxicity than bupivacaine. Ropivacaine may offer advantages when used for thoracic paravertebral block. This study was designed to describe the pharmacokinetics of ropivacaine after thoracic paravertebral block. METHODS Twenty female patients undergoing elective unilateral breast s...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 2002

ISSN: 0007-0912

DOI: 10.1093/bja/89.3.438